Cyclooxygenase-2 in Synaptic Signaling
نویسندگان
چکیده
منابع مشابه
The Role of Cyclooxygenase-2 in Signaling Pathways Promoting Colorectal Cancer
Colorectal cancer is one of the most common cancers in the world. Various factors are involved in the development and progression of this disease. One of these agents is cyclooxygenase-2 (COX-2). COX-2 is a product of the PTGS2 gene and converts free arachidonic acid to prostaglandins. COX-2 is not naturally expressed in most normal cells. Noticeably, the increased expression of COX-2 has been ...
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The functional significance of cyclooxygenases (COX-1 and -2), the key enzymes that convert arachidonic acid (AA) to prostaglandins (PGs) in brain, is unclear, although they have been implicated in cellular functions and in some neurologic disorders, including stroke, epilepsy, and Alzheimer's disease. Recent evidence that COX-2 is expressed in postsynaptic dendritic spines (which are specializ...
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Introduction: cyclooxygenase-2 (COX-2) is involved in pathogenesis of various tumors and possibly malignant skin tumors including malignant melanoma; however, there is not enough information about COX-2 expression in benign melanocytic lesions. In the present study we compared the expression levels of COX-2 in malignant melanoma and benign melanocytic lesions. Method: In this analytical study, ...
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Epilepsy is one of the more prevalent neurologic disorders in the world, affecting approximately 50 million people of different ages and backgrounds. Epileptic seizures propagating through both lobes of the forebrain can have permanent debilitating effects on a patient's cognitive and somatosensory brain functions. Epilepsy, defined by the sporadic occurrence of spontaneous recurrent seizures (...
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background: lymphomas are a group of malignancies affecting b, t and nk cells. cox-2 enzyme is one of the known inflammatory factors which increase in the inflammation process. increase in cox-2 expression inhibits apoptosis and increases tumor cells invasion and angiogenesis. increase in the cox-2 gene expression is seen in a group of cancers .specific cox-2 inhibition also can be beneficial i...
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ژورنال
عنوان ژورنال: Current Pharmaceutical Design
سال: 2008
ISSN: 1381-6128
DOI: 10.2174/138161208784480144